反应详情

A solution of 2-(4-chlorophenyl)-N-[4-(dimethylamino)phenyl]-N-methyl-3H-imidazo[4,5-b]pyridine-3-acetamide (5.6 g, 0.0133 mole) in hot isopropyl alcohol was acidified with hydrogen chloride in isopropyl alcohol. Isopropyl ether was added to precipitate a solid. The solid was collected by filtration, rinsed with isopropyl ether, and dried under high vacuum to give 3.74 g (52%) of title compound, mp 120°-132° C. (shrinks), 150°-155° C. (melts).

1. customto precipitate a solid
2. filtrationThe solid was collected by filtration
3. washrinsed with isopropyl ether
4. customdried under high vacuum