Potassium Iodide → HCID 19857170, compound

HRID 2073496Notes

Reaction equation

HRID 2073496 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH2:9][CH2:10][CH2:11]Br)=[CH:4][CH:3]=1.[OH:20][CH2:21][CH2:22][CH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1.C(N(CC)CC)C.[I-].[K+]>CN(C)C=O.C(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH2:9][CH2:10][CH2:11][N:26]2[CH2:27][CH2:28][CH:23]([CH2:22][CH2:21][OH:20])[CH2:24][CH2:25]2)=[CH:4][CH:3]=1

Participants

7

Reactant 4

HCID 4875Potassium IodideHCID 8471TriethylamineHCID 739534-PiperidineethanolHCID 937631,1'-(4-Bromobutylidene)bis[4-fluorobenzene]

Product 1

HCID 19857170HCID 19857170, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 6344DichloromethaneSolvent

Procedure

20 g (62 mmol) of 4,4-bis(4-fluorophenyl)butyl bromide, 8.8 g (68 mmol) of 4-hydroxyethylpiperidine, 12.5 g (124 mmol) of triethylamine and 0.1 g of potassium iodide were stirred in 200 ml of absolute dimethylformamide at 80° C. for 4.5 hours. The solvent was stripped off in vacuo, the residue was taken up in methylene chloride, the mixture was extracted by shaking with 2N HCl, water and NaCl solution and the extract was dried and concentrated.

Workup

  1. extractionthe mixture was extracted
  2. customthe extract was dried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-93b725a4099c46ceafa5c98225c72c9f
Source dataset
uspto-grants-1990_04
Patent number
US04918073

Reaction notes

Loading…