Ammonium Hydroxide → HCID 14800670, compound

HRID 2073875Notes

Reaction equation

HRID 2073875 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:28]=[CH:27][C:16]([CH2:17][C:18]2[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=2)[C:21](Cl)=[O:22])=[CH:15][CH:14]=1.[OH-].[NH4+:30]>O1CCCC1>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:28]=[CH:27][C:16]([CH2:17][C:18]2[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=2)[C:21]([NH2:30])=[O:22])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 14800669HCID 14800669, compound

Product 1

HCID 14800670HCID 14800670, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-(4-(2-Quinolinylmethyloxy)benzyl)benzoyl chloride (0.05 mol) in tetrahydrofuran (300 ml) is treated with concentrated ammonium hydroxide (25 ml). The reaction mixture is stirred overnight at room temperature and then evaporated and partitioned between ethyl acetate and water. The ethyl acetate fraction is dried and evaporated to give 3-(4-(2-quinolinylmethyloxy)benzyl)benzamide.

Workup

  1. customevaporated
  2. custompartitioned between ethyl acetate and water
  3. dry with materialThe ethyl acetate fraction is dried
  4. customevaporated

Sources & evidence

ORD record
ord-720298537d57402a9ac60946355ead25
Source dataset
uspto-grants-1990_04
Patent number
US04920133

Reaction notes

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