反应详情

Under argon, 15 g (81 mmol) of ethyl 4-nitro-1H-imidazole-2-carboxylate are stirred with 13.13 g (97.2 mmol) of cyclopropylmethyl bromide and 22.4 g (162 mmol) of potassium carbonate in 165 ml of DMF at 80° C. for 1 h. After cooling, the reaction mixture is diluted with water and extracted four times with ethyl acetate. The combined organic phases are washed once with water and three times with a saturated sodium chloride solution, dried with magnesium sulfate and concentrated in vacuo. The crystalline residue is directly used further for the next reaction.

1. temperatureAfter cooling
2. extractionextracted four times with ethyl acetate
3. washThe combined organic phases are washed once with water and three times with a saturated sodium chloride solution
4. dry with materialdried with magnesium sulfate
5. concentrationconcentrated in vacuo
6. customThe crystalline residue is directly used further for the next reaction