反应详情

(S)-2-Aminomethyl-pyrrolidine-1-carboxylic acid tert butyl ester (2 g), 5-bromo-2-chloropyrimidine (1.93 g) were combined in xylene (40 ml) containing potassium carbonate (2.76 g) and diisopropylethylamine (5.23 ml) and warmed to reflux for 20 h. The mixture was cooled to room temperature, filtered and solvent removed at reduced pressure. The residue was column chromatographed (silica gel, pentane—25% ethyl acetate/pentane). The appropriate fractions were collected, solvent removed at reduced pressure to give the title compound (1.78 g) as a colourless gum

1. temperaturewarmed
2. temperatureto reflux for 20 h
3. filtrationfiltered
4. customsolvent removed at reduced pressure
5. customchromatographed (silica gel, pentane—25% ethyl acetate/pentane)
6. customThe appropriate fractions were collected
7. customsolvent removed at reduced pressure