反应详情

To a slurry of 2-fluoro-4-formylbenzoic acid (0.500 g, 3.0 mmol) in 8 mL DCM was added 2 drops N,N-dimethylformamide (0.011 g, 0.15 mmol), followed by oxalyl dichloride (0.39 mL, 4.5 mmol). After 30 min, the reaction became clear, light yellow, and homogeneous. The reaction was evaporated and dried in vacuo. The resulting solid was suspended in 10 mL THF, and 2-amino-4-phenoxyphenol (0.60 g, 3.0 mmol) was added as a solid followed by Hunig's base (0.67 mL, 3.9 mmol). The resulting brown solution became warm, and was allowed to stir for overnight. The reaction was diluted with DCM and 1N HCl. The aq. layer was extracted 1×DCM, and the organics were dried over sodium sulfate, filtered, and concentrated to give a brown solid. This was treated with 4-methylbenzenesulfonic acid hydrate (0.85 g, 4.5 mmol) and 10 mL toluene. The reaction was fitted with a water-cooled reflux condensor and drying tube, and placed in a 120° C. bath for ˜4 h, cooled and partitioned between DCM and 1N NaOH with stirring. The reaction was filtered, and the aq. layer was extracted 1×DCM. The combined organics were dried over sodium sulfate, filtered, and concentrated to give an orange oil which was purified by ISCO, 0-30% EtOAc/hexanes to give title compound as an off-white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 10.10 (s, 1H), 8.45 (t, J=7.5 Hz, 1H), 7.94-8.02 (m, 2H), 7.90 (d, J=9.0 Hz, 1H), 7.54 (d, J=2.0 Hz, 1H), 7.37-7.46 (m, 2H), 7.22 (dd, J=8.8, 2.3 Hz, 1H), 7.15 (t, J=7.3 Hz, 1H), 7.04 (d, J=8.5 Hz, 2H).

1. customThe reaction was evaporated
2. customdried in vacuo
3. temperatureThe resulting brown solution became warm
4. extractionThe aq. layer was extracted 1×DCM
5. dry with materialthe organics were dried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated
8. customto give a brown solid
9. temperaturecooled
10. temperaturereflux condensor
11. customdrying tube
12. customplaced in a 120° C.
13. customfor ˜4 h
14. temperaturecooled
15. custompartitioned between DCM and 1N NaOH
16. stirringwith stirring
17. filtrationThe reaction was filtered
18. extractionthe aq. layer was extracted 1×DCM
19. dry with materialThe combined organics were dried over sodium sulfate
20. filtrationfiltered
21. concentrationconcentrated
22. customto give an orange oil which
23. customwas purified by ISCO, 0-30% EtOAc/hexanes