4-Methylmorpholine → HCID 67089723, compound

HRID 2075451Notes

Reaction equation

HRID 2075451 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](/[CH:10]=[CH:11]/[C:12]2[CH:28]=[CH:27][C:15]([C:16]([N:18]3[CH2:23][CH2:22][CH:21]([C:24](O)=[O:25])[CH2:20][CH2:19]3)=[O:17])=[CH:14][CH:13]=2)=[N:2]1.Cl.[CH3:30][NH:31][CH3:32].O.ON1C2C=CC=CC=2N=N1.Cl.C(N=C=NCCCN(C)C)C.CN1CCOCC1>>[CH3:30][N:31]([CH3:32])[C:24]([CH:21]1[CH2:20][CH2:19][N:18]([C:16](=[O:17])[C:15]2[CH:27]=[CH:28][C:12](/[CH:11]=[CH:10]/[C:3]3[C:4]4[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=4)[NH:1][N:2]=3)=[CH:13][CH:14]=2)[CH2:23][CH2:22]1)=[O:25]

Participants

6

Reactant 5

HCID 79724-MethylmorpholineHCID 10473Dimethylamine, hydrochlorideHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 27960291-Hydroxybenzotriazole hydrateHCID 67090453HCID 67090453, compound

Product 1

HCID 67089723HCID 67089723, compound

Procedure

In a similar manner to Example 5, Compound 9-2 (27 mg, 5%) was obtained using Compound 50 (500 mg, 1.33 mmol), dimethylamine hydrochloride (230 mg, 1.50 mmol), 1-hydroxybenzotriazole monohydrate (306 mg, 2.00 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride mg, 2.00 mmol) and N-methylmorpholine (0.439 mL, 4.00 mmol).

Sources & evidence

ORD record
ord-65e9ccc81c3346d2bce198b5b390cb32
Source dataset
uspto-grants-2011_04
Patent number
US07919517B2

Reaction notes

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