反应详情

The crude product obtained using dihydrochloride of Compound 18 (300 mg, 0.741 mmol), N-methylmorpholine (0.163 mL, 1.48 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (199 mg, 1.04 mmol), 1-hydroxybenzotriazole monohydrate (130 mg, 0.963 mmol) and ethoxyacetic acid (0.0700 mL, 0.741 mmol) in a similar manner to Example 5, was purified by silica gel column chromatography (chloroform/methanol=90/10), followed by recrystallization from mixed solvent of ethyl acetate/methanol to obtain Compound 128 (62.0 mg, 20%).

1. customwas purified by silica gel column chromatography (chloroform/methanol=90/10)
2. customfollowed by recrystallization
3. additionfrom mixed solvent of ethyl acetate/methanol