反应详情

温度

130 °C

8a (497 mg, 2.46 mmol) and dimethoxymethyldimethylamine (1 mL) were combined in DMF (5 mL) and heated to 130° C. for 1 hour. The reaction was concentrated and redissolved in MeOH (5 mL) and pyridine (400 mg). Hydroxylamine-O-sulfonic acid (282 mg, 2.49 mmol) was added, and the mixture was stirred at room temperature for 3 days. The solution was concentrated and poured into water, and the resulting solid was filtered and dried to give the desired product, 8b.

1. concentrationThe reaction was concentrated
2. dissolutionredissolved in MeOH (5 mL)
3. concentrationThe solution was concentrated
4. additionpoured into water
5. filtrationthe resulting solid was filtered
6. customdried