Hydroxyamine hydrochloride → HCID 58257762, compound

HRID 2075731Notes

Reaction equation

HRID 2075731 reaction equation
C(=[N:14][C:15]1[CH:24]=[C:23]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:22]2[C:17](=[CH:18][C:19]([S:31][C:32]3[CH:33]=[C:34]([C:38]([OH:43])([CH2:41][CH3:42])[CH2:39][CH3:40])[CH:35]=[CH:36][CH:37]=3)=[CH:20][CH:21]=2)[N:16]=1)(C1C=CC=CC=1)C1C=CC=CC=1.Cl.NO.C([O-])(=O)C.[K+]>CO>[NH2:14][C:15]1[CH:24]=[C:23]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:22]2[C:17](=[CH:18][C:19]([S:31][C:32]3[CH:33]=[C:34]([C:38]([OH:43])([CH2:41][CH3:42])[CH2:39][CH3:40])[CH:35]=[CH:36][CH:37]=3)=[CH:20][CH:21]=2)[N:16]=1

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517044Potassium AcetateHCID 58257768HCID 58257768, compound

Product 1

HCID 58257762HCID 58257762, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10p (990 mg, 15.5 mmol), hydroxylamine hydrochloride (220 mg, 31.1 mmol), and potassium acetate (310 mg, 31.1 mmol) were dissolved in MeOH (1.5 mL) and stirred overnight at room temperature. The reaction was concentrated and purified by silica gel chromatography (30% EtOAc in hexanes) to give the desired product, 10q.

Workup

  1. concentrationThe reaction was concentrated
  2. custompurified by silica gel chromatography (30% EtOAc in hexanes)

Sources & evidence

ORD record
ord-2654cc6d3bc445fbb6e8a984db406cf6
Source dataset
uspto-grants-2011_04
Patent number
US07919621B2

Reaction notes

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