反应详情

Tin(II) chloride dihydrate (21 g) was added to a suspension of 6-chloro-4-methylamino-3-nitro-pyridine-2-carbonitrile (6.6 g) in ethanol (150 ml). The mixture was stirred at room temperature for 3 hours. To above red-brown coloured solution was then added ethyl acetate (1000 ml) and followed by 10% aqueous ammonium hydroxide (200 ml). The organic layer were separated, the sticky solid pad was washed with ethyl acetate (5×200 ml). Combined organic layer was then washed with saturated sodium chloride aqueous solution (2×200 ml), dried over sodium sulphate, solvent removed to give a brown solid as expected product (5.7 g).

1. customThe organic layer were separated
2. washthe sticky solid pad was washed with ethyl acetate (5×200 ml)
3. washCombined organic layer was then washed with saturated sodium chloride aqueous solution (2×200 ml)
4. dry with materialdried over sodium sulphate, solvent
5. customremoved