反应详情

Method N Combine 4-(6-nitro-1H-indol-3-yl)-benzonitrile, 9, (290 mg, 1.1 mmol), 4-dimethylaminopyridine (14 mg, 0.11 mmol), triethyl amine (740 μL, 5.3 mmol), methylene chloride (7.0 mL) and dimethylformamide (2.5 mL) in a 25 mL flask. Add 3-pyridine sulfonyl chloride hydrochloride (283 mg, 1.32 mmol). Let the solution stir overnight. Isolate the precipitate by filtration and wash the precipitate 3× with methylene chloride to yield 251 mg, 0.62 mmol, 56% of the title compound. LRMS (API ES+)=405.0 (M+H).

1. customIsolate the precipitate
2. filtrationby filtration
3. washwash the precipitate 3× with methylene chloride