反应详情

温度

60 °C

Method Z-2 Place N-[3-(4-formyl-phenyl)-1-isopropyl-1H-indol-6-yl]-methanesulfonamide and hydroxylamine hydrochloride into a round bottom flask under nitrogen. Add ethanol (10 mL), tetrahydrofuran (10 mL) and pyridine. Warm to 60° C., and stir for 2 hours. Dilute with ethyl acetate (20 mL), and wash with 1N hydrochloric acid. Dry the organic layer over sodium sulfate, and concentrate in vacuo. Purify the residue by flash chromatography on silica (5-40% ethyl acetate in dichloromethane) to give N-{3-[4-(Hydroxyimino-methyl)-phenyl]-1-isopropyl-1H-indol-6-yl}-methanesulfonamide (241.1 mg, 69%). LRMS (API ES+)=372.0 (M+H).

1. washwash with 1N hydrochloric acid
2. dry with materialDry the organic layer over sodium sulfate
3. concentrationconcentrate in vacuo
4. customPurify the residue by flash chromatography on silica (5-40% ethyl acetate in dichloromethane)