反应详情

The hydrochloride (203 mg) of the compound obtained in Example 65-1 was dissolved in DMF (3.0 ml) and added with cinnamyl alcohol (73.9 μl) and the whole was refluxed overnight under heating. After completion of the reaction, the solvent was distilled off. The resultant was dissolved in chloroform and added with a saturated aqueous sodium hydrogen carbonate solution and the whole was stirred for a while. The solution was subjected to extraction with chloroform and washed with a saturated saline solution. The organic layer was dried with anhydrous sodium sulfate. The solvent was distilled off. The residue was purified through silica gel column chromatography (chloroform/ethyl acetate) and treated with hydrochloric acid, thereby obtaining a hydrochloride (19.1 mg) of the subject compound as a brownish-red solid.

1. temperaturethe whole was refluxed overnight
2. temperatureunder heating
3. customAfter completion of the reaction
4. distillationthe solvent was distilled off
5. dissolutionThe resultant was dissolved in chloroform
6. additionadded with a saturated aqueous sodium hydrogen carbonate solution
7. extractionThe solution was subjected to extraction with chloroform
8. washwashed with a saturated saline solution
9. dry with materialThe organic layer was dried with anhydrous sodium sulfate
10. distillationThe solvent was distilled off
11. customThe residue was purified through silica gel column chromatography (chloroform/ethyl acetate)
12. additiontreated with hydrochloric acid