反应详情

To a stirred mixture of 1.88 g (0.0067 mole) of 3-[3-(trifluoromethyl)phenoxy]-1-azetidinecarbonyl chloride and 1 g (0.007 mole) of potassium carbonate was added 20 ml of tetrahydrofuran and 0.75 g (0.007 mole) of 4-toluidine. After stirring for 0.5 hr, ice was added and stirring continued for 18 hr. The reaction mixture was diluted with water and then decanted from an oil residue which separated. Upon standing, this residue solidified and was recrystallized from acetone to yield 1.1 g (47%) of large, white crystals, m.p. 191°-192° C.

1. additionice was added
2. stirringstirring
3. waitcontinued for 18 hr
4. customdecanted from an oil residue which
5. customseparated
6. customthis residue solidified and was recrystallized from acetone
7. customto yield 1.1 g (47%) of large, white crystals, m.p. 191°-192° C.