Water → HCID 19367598, compound

HRID 2081778Notes

Reaction equation

HRID 2081778 reaction equation
[F-:1].[K+].C1OCCOCCOCCOCCOCCOC1.Cl[C:22]1[N:31]2[CH:32]=[C:33]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=3[F:41])[N:34]=[C:30]2[C:29]2[CH2:28][CH2:27][CH2:26][CH2:25][C:24]=2[N:23]=1.O>CN(C=O)C>[F:1][C:22]1[N:31]2[CH:32]=[C:33]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=3[F:41])[N:34]=[C:30]2[C:29]2[CH2:28][CH2:27][CH2:26][CH2:25][C:24]=2[N:23]=1

Participants

6

Reactant 4

HCID 962WaterHCID 2855718-Crown-6HCID 522689Potassium FluorideHCID 15284102HCID 15284102, compound

Product 1

HCID 19367598HCID 19367598, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 700 mg of potassium fluoride and 200 mg 18-crown-6 in 10 mL of DMF was added 5-Chloro-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazoline (200 mg). This mixture was refluxed for 1.5 h, cooled to room temperature and poured into water. The aqueous solution was extracted with ethyl acetate, the organic layer was separated and dried, and the solvent removed in vacuo to yield 5-Fluoro-2-(2-fluorophenyl)-7,8,9,10-tetrahydro-imidazo[1,2-c]-quinazoline (Compound 41), m.p. 154°-155° C.

Workup

  1. temperatureThis mixture was refluxed for 1.5 h
  2. extractionThe aqueous solution was extracted with ethyl acetate
  3. customthe organic layer was separated
  4. customdried
  5. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-cfa177f108f14b538b8164ef118d0c3e
Source dataset
uspto-grants-1993_02
Patent number
US05185446

Reaction notes

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