N-Methylbenzylamine → HCID 10406733, compound

Temperature

-35 °C

A solution of Boc-Phe-OH (5.48 g) and NMM (2.09 g) in methylene chloride (50 ml) was cooled to -20° C. To this solution was added dropwise isobutyl chloroformate (2.82 g) maintaining the temperature between -22° C. to -20° C. in 7 minutes. After stirring the mixture for 20 minutes at the same temperature, the solution was cooled to -35° C. and HNMeBzl (2.50 g) was added dropwise to the solution. The reaction mixture was stirred for 2 hours during which period the temperature was gradually raised to -2° C. The solution was washed successively with water (twice), diluted sodium hydrogencarbonate solution (twice), water 0.5N hydrochloric acid (twice), and sodium chloride solution, and dried over magnesium sulfate. After evaporation, the solidified residue was pulverized in hot diisopropyl ether (10 ml), and after cooling, n-hexane (30 ml) was added to the mixture. The crystalline solid was filtered, washed with n-hexane (5 ml×2), and dried to give Boc-Phe-NMeBzl (6.49 g).

1. temperaturemaintaining the temperature between -22° C. to -20° C. in 7 minutes
2. stirringThe reaction mixture was stirred for 2 hours during which period the temperature
3. temperaturewas gradually raised to -2° C
4. washThe solution was washed successively with water (twice), diluted sodium hydrogencarbonate solution (twice), water 0.5N hydrochloric acid (twice), and sodium chloride solution
5. dry with materialdried over magnesium sulfate
6. customAfter evaporation
7. temperatureafter cooling
8. additionn-hexane (30 ml) was added to the mixture
9. filtrationThe crystalline solid was filtered
10. washwashed with n-hexane (5 ml×2)
11. customdried

ORD record

ord-c30fd431323c486aa96c02e241b054e4

Source dataset

uspto-grants-1993_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05187156