Potassium Carbonate → HCID 19778085, compound

HRID 2082303Notes

Reaction equation

HRID 2082303 reaction equation
[CH3:1][N:2]1[C:6]([OH:7])=[C:5]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=2[Cl:16])[C:4]([CH3:17])=[N:3]1.[Cl:18][C:19]1[N:24]=[C:23](Cl)[CH:22]=[CH:21][N:20]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH3:1][N:2]1[C:6]([O:7][C:21]2[CH:22]=[CH:23][N:24]=[C:19]([Cl:18])[N:20]=2)=[C:5]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=2[Cl:16])[C:4]([CH3:17])=[N:3]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 775312,4-DichloropyrimidineHCID 178434067HCID 178434067, compound

Product 1

HCID 19778085HCID 19778085, compoundYield 42.5%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

In 10 ml of acetonitrile were stirred 2.7 g (10 mmol) of 1,3-dimethyl-4-(2,4-dichlorobenzyl)-5-hydroxypyrazole, 1.5 g (10 mmol) of 2,4-dichloropyrimidine and 1.5 g (11 mmol) of potassium carbonate with refluxing for 3 hours. After completing the reaction, the reaction mixture was purified as the same manner as described in Example 4 to give 1.63 g of 1,3-dimethyl-4-(2,4-dichlorobenzyl)-5-(2-chloropyrimidine-4-yloxy)pyrazole.

Workup

  1. temperaturewith refluxing for 3 hours
  2. customthe reaction
  3. customthe reaction mixture was purified as the same manner

Sources & evidence

ORD record
ord-1c8507ebdd9b4af1b0001b536289d498
Source dataset
uspto-grants-1993_02
Patent number
US05189040

Reaction notes

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