Diethyl Ether → HCID 13427304, compound

HRID 2082329Notes

Reaction equation

HRID 2082329 reaction equation
[P:1]([Cl:5])(Cl)(Cl)=[O:2].[CH2:6]([OH:14])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.C(N([CH2:20][CH3:21])CC)C.C([O:24][CH2:25][CH3:26])C>>[C:8]1([CH2:7][CH2:6][O:14][P:1]([Cl:5])([O:24][CH2:25][CH2:26][C:21]2[CH:20]=[CH:9][CH:8]=[CH:7][CH:6]=2)=[O:2])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

5

Reactant 4

HCID 3283Diethyl Ether3×HCID 60542-PhenylethanolHCID 8471TriethylamineHCID 24813Phosphorus oxychloride

Product 1

HCID 13427304HCID 13427304, compound

Conditions

Temperature
0 °C

Procedure

To a solution of phosphorus oxychloride ((1.53 g, 10 mmol) in anhydrous diethyl ether (20 ml), cooled at 0° C. under argon, is added a solution of 2.44 g (20 mmol) of phenethyl alcohol in diethyl ether (5 ml), followed by 2.02 g (20 mmol) of triethylamine in diethyl ether (5 ml). The mixture is stirred for 1 hour at 0° C., and then for 17 hours at room temperature. The final suspension is filtered, and the filtrate is evaporated to give 3.07 g of a colorless liquid.

Workup

  1. waitfor 17 hours at room temperature
  2. filtrationThe final suspension is filtered
  3. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-ab82b1df4ee74f4aaa6e79799f5f8c7d
Source dataset
uspto-grants-1993_02
Patent number
US05189023

Reaction notes

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