Hydrochloric Acid → HCID 70618533, compound

HRID 2082672Notes

Reaction equation

HRID 2082672 reaction equation
C(OC([NH:8][C@H:9]([C:13]([NH:15][C@@H:16]([C:29](=[O:31])[NH2:30])[CH2:17][CH2:18][C:19]([O:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:20])=[O:14])[CH:10]([CH3:12])[CH3:11])=O)(C)(C)C.[ClH:32].CCOCC>C(OCC)(=O)C>[ClH:32].[NH2:8][C@H:9]([C:13]([NH:15][C@@H:16]([C:29](=[O:31])[NH2:30])[CH2:17][CH2:18][C:19]([O:21][CH2:22][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)=[O:20])=[O:14])[CH:10]([CH3:12])[CH3:11]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 40592955HCID 40592955, compound

Product 1

HCID 70618533HCID 70618533, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 0.44 g of benzyl t-butyloxycarbonyl-L-valyl-D-isoglutaminate (7, n = 2, X1 = L-valyl) at 22° C there is added 5 ml of a saturated solution of hydrogen chloride in ethyl acetate. After 20 minutes, 40 ml of ether is added and the precipitated salt is collected by centrifugation and carefully dried in vacuo to give benzyl L-valyl-D-isoglutaminate hydrochloride (10, n = 2, X1 = L-valyl).

Workup

  1. customthe precipitated salt is collected by centrifugation
  2. customcarefully dried in vacuo

Sources & evidence

ORD record
ord-f94eff23dba743da9f1113b730c914f8
Source dataset
uspto-grants-1978_04
Patent number
US04082736

Reaction notes

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