1,2-Epoxybutane → HCID 12320209, compound

HRID 2082680Notes

Reaction equation

HRID 2082680 reaction equation
[Na].[Cl:2][C:3]1[NH:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[Cl-].[Cl-].[Ca+2].[O:15]1[CH:17]([CH2:18][CH3:19])[CH2:16]1>>[OH:15][CH:17]([CH2:18][CH3:19])[CH2:16][N:4]1[C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=[C:3]1[Cl:2]

Participants

5

Reactant 4

HCID 78341,2-EpoxybutaneHCID 785722-ChlorobenzimidazoleHCID 5284359Calcium ChlorideHCID 5360545Sodium

Product 1

HCID 12320209HCID 12320209, compound

Procedure

5 g of the sodium salt of 2-chlorobenzimidazole are suspended in 50 ml of epoxybutane in a flask provided with a reflux condenser and a CaCl2 plug. The mixture is boiled for 15 hours, the epoxybutane is then evaporated under vacuum and the residue is taken up with water and made alkaline with 10% sodium hydrate. After agitation for about 1 hour it is filtered and the residue obtained is crystallised twice from benzene. A white product is obtained which melts at 126°.

Workup

  1. customprovided with a reflux condenser
  2. customthe epoxybutane is then evaporated under vacuum
  3. filtrationAfter agitation for about 1 hour it is filtered
  4. customthe residue obtained
  5. customis crystallised twice from benzene
  6. customA white product is obtained which melts at 126°

Sources & evidence

ORD record
ord-6148dc7d4d364d07a735f5c355f85fcb
Source dataset
uspto-grants-1978_04
Patent number
US04082760

Reaction notes

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