Hydrochloric Acid → HCID 178446014, compound

HRID 2083829Notes

Reaction equation

HRID 2083829 reaction equation
[ClH:1].C(OC([NH:9][C@@H:10]([C:21]([NH:23][C@H:24]([C:29]([NH:31][C@H:32]([C:40]([N:42]1[CH2:53][CH2:52][CH2:51][C@H:43]1[C:44]([NH:46][CH2:47][C:48]([NH2:50])=[O:49])=[O:45])=[O:41])[CH2:33][CH2:34][CH2:35][NH:36][C:37](=[NH:39])[NH2:38])=[O:30])[CH2:25][CH:26]([CH3:28])[CH3:27])=[O:22])[CH2:11][C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[NH:14][CH:13]=1)=O)(C)(C)C.CO.Cl>O1CCCC1>[ClH:1].[ClH:1].[NH2:9][C@@H:10]([C:21]([NH:23][C@H:24]([C:29]([NH:31][C@H:32]([C:40]([N:42]1[CH2:53][CH2:52][CH2:51][C@H:43]1[C:44]([NH:46][CH2:47][C:48]([NH2:50])=[O:49])=[O:45])=[O:41])[CH2:33][CH2:34][CH2:35][NH:36][C:37](=[NH:38])[NH2:39])=[O:30])[CH2:25][CH:26]([CH3:27])[CH3:28])=[O:22])[CH2:11][C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[NH:14][CH:13]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 178445965HCID 178445965, compound

Product 1

HCID 178446014HCID 178446014, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 1.69 g. of Nα -t-butoxycarbonyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolyl-glycinamide hydrochloride in 20 ml. of methanol and 10 ml. of 3N hydrogen chloride in 10 ml. of tetrahydrofuran is allowed to stand for 1 hour and then evaporated to dryness at 30° C. under reduced pressure. The residue is twice dissolved in 20 ml. of methanol and the solvent evaporated. It is then dried at 45° C. under reduced pressure. The product is used without further purification.

Workup

  1. customevaporated to dryness at 30° C. under reduced pressure
  2. dissolutionThe residue is twice dissolved in 20 ml
  3. customof methanol and the solvent evaporated
  4. customIt is then dried at 45° C. under reduced pressure
  5. customThe product is used without further purification

Sources & evidence

ORD record
ord-9fd4746e74db4519a170b20ac400672f
Source dataset
uspto-grants-1978_04
Patent number
US04086219

Reaction notes

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