HCID 9925480, compound → 6-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

HRID 2084053Notes

Reaction equation

HRID 2084053 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([CH:12]=[CH:13][N:14]3C(C)C)=[CH:10][CH:9]=2)=[CH:4][CH2:3]1.OC1(C2C=C3C(C=CN3C(C)C)=CC=2)CCN(C)CC1>C(O)(C(F)(F)F)=O.C1COCC1>[CH3:1][N:2]1[CH2:7][CH2:6][C:5]([C:8]2[CH:16]=[C:15]3[C:11]([CH:12]=[CH:13][NH:14]3)=[CH:10][CH:9]=2)=[CH:4][CH2:3]1

Participants

5

Reactant 2

HCID 9925480HCID 9925480, compoundHCID 10131267HCID 10131267, compound

Product 1

HCID 101305596-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

Reagents, catalysts & solvents 2

HCID 6422Trifluoroacetic acidSolventHCID 8028TetrahydrofuranSolvent

Procedure

6-[N-Methyl-1,2,5,6-tetrahydropyridin-4-yl]-1-isopropyl-indole : from 6-[4-Hydroxy-1-methyl-piperidin-4-yl]-1-isopropyl-indole (20 mg, 0.0735 mmol) in 0.1 ml of TFA and 1 ml of THF at 60-64° C. Yield 4.8 mg (26%).

Workup

  1. customat 60-64° C

Sources & evidence

ORD record
ord-d5d20d774d204093aa8aeb7165fe83a1
Source dataset
uspto-grants-2004_04
Patent number
US06716837B1

Reaction notes

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