反应详情

To a solution of 4-(4-hydroxyphenyl)-1-butanol (1.99 g) in DMF (20 ml), 60% oily sodium hydride (528 mg) was added under ice cooling, followed by stirring at room temperature for 30 minutes. Under ice cooling, (E)-4-chloromethyl-2-[2-(2,4-difluorophenyl)ethenyl]oxazole (3.37 g) was added, followed by stirring overnight at room temperature. After water and 1 N hydrochloric acid was added, the reaction mixture was extracted with ethyl acetate. After the extract was dried over magnesium sulfate, it was concentrated under reduced pressure; the residue was recrystallized from ethyl acetate-diethyl ether-hexane to yield the titled compound (3.71 g) as colorless crystals.

1. stirringby stirring overnight at room temperature
2. extractionthe reaction mixture was extracted with ethyl acetate
3. dry with materialAfter the extract was dried over magnesium sulfate, it
4. concentrationwas concentrated under reduced pressure
5. customthe residue was recrystallized from ethyl acetate-diethyl ether-hexane