反应详情

To a suspension of sodium hydride (60% in oil, 5.19 g) in N,N-dimethylformamide (30 ml) was added a solution of 3′-nitroacetanilide (214 mg) in N,N-dimethylformamide (30 ml) at 0° C. The mixture was stirred at room temperature for 30 minutes, then iodomethane (3.59 ml) was added. After 30 minutes, 1N hydrochloric acid was poured into the mixture and extracted with ethyl acetate. The organic solution was washed with water and brine, dried over magnesium sulfate and concentrated. The resultant solid was collected and washed with isopropyl ether to give N-methyl-3′-nitroacetanilide (4.64 g).

1. waitAfter 30 minutes
2. extractionextracted with ethyl acetate
3. washThe organic solution was washed with water and brine
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated
6. customThe resultant solid was collected
7. washwashed with isopropyl ether