Triethylamine → HCID 711488, compound

HRID 2086815Notes

Reaction equation

HRID 2086815 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([Cl:9])[CH:8]=1)[NH2:5].C(N(CC)CC)C.[N+:17]([C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][CH:28]=1)[C:23](Cl)=[O:24])([O-:19])=[O:18].C(=O)(O)[O-].[Na+]>C(Cl)(Cl)Cl>[N+:17]([C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][CH:28]=1)[C:23]([NH:5][C:4]1[CH:3]=[C:2]([Cl:1])[CH:8]=[C:7]([Cl:9])[CH:6]=1)=[O:24])([O-:19])=[O:18]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 8495Benzoyl chloride, 3-nitro-HCID 122813,5-DichloroanilineHCID 516892Sodium Bicarbonate

Product 1

HCID 711488HCID 711488, compoundYield 80.4%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

To a mixture of 3,5-dichloroaniline (8.1 g) and triethylamine (7.0 ml) in chloroform (100 ml) was added dropwise a solution of 3-nitrobenzoyl chloride (9.3 g) in chloroform (50 ml). The mixture was stirred at room temperature for 1 hour, then poured into aqueous sodium bicarbonate. The resultant precipitate was collected and washed with chloroform and water to give 3-nitro-N-(3,5-dichlorophenyl)benzamide (12.50 g).

Workup

  1. customThe resultant precipitate was collected
  2. washwashed with chloroform and water

Sources & evidence

ORD record
ord-489361959ee04e3794c574c0e6d5ca14
Source dataset
uspto-grants-2004_04
Patent number
US06727245B2

Reaction notes

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