3-Bromopropylamine hydrobromide → tert-butyl N-(3-bromopropyl)carbamate

HRID 2087129Notes

Reaction equation

HRID 2087129 reaction equation
Br.[Br:2][CH2:3][CH2:4][CH2:5][NH2:6].[O:7](C(OC(C)(C)C)=O)[C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=O>ClCCl>[Br:2][CH2:3][CH2:4][CH2:5][NH:6][C:8](=[O:7])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12]

Participants

4

Reactant 2

HCID 787013-Bromopropylamine hydrobromideHCID 90495Di-tert-butyl dicarbonate

Product 1

HCID 4460490tert-butyl N-(3-bromopropyl)carbamate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared from 3-bromopropylamine hydrobromide and BOC2O in the presence of base in dichloromethane, 9.89 mmol: 1H NMR (CDCl3) δ 5.07 (br, 1H), 3.31 (t, 2H, J=6.6 Hz), 3.12 (apparent br q, 2H, J=6.0 Hz), 1.92 (p, 2H, J=6.6 Hz), 1.30 (s, 9H).

Sources & evidence

ORD record
ord-887ae971ac1143569bfedbd7fb3a8829
Source dataset
uspto-grants-2004_04
Patent number
US06727264B1

Reaction notes

Loading…