Hydrochloric Acid → {4-[(5-Bromo-2-chloro-pyrimidin-4-ylamino)-methyl]-cyclohexyl}-carbamic acid tert-butyl ester

HRID 208735Notes

Reaction equation

HRID 208735 reaction equation
[Br:1][c:2]1[c:3]([Cl:9])[n:4][c:5]([Cl:8])[n:6][cH:7]1.[C:11]([CH3:12])([CH3:13])([CH3:14])[O:15][C:16]([NH:17][CH:18]1[CH2:19][CH2:20][CH:21]([CH2:24][NH2:25])[CH2:22][CH2:23]1)=[O:26].[CH:27]([N:28]([CH2:29][CH3:30])[CH:31]([CH3:32])[CH3:33])([CH3:34])[CH3:35].[ClH:10]>>[Br:1][c:2]1[c:3]([NH:25][CH2:24][CH:21]2[CH2:20][CH2:19][CH:18]([NH:17][C:16]([O:15][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:26])[CH2:23][CH2:22]2)[n:4][c:5]([Cl:8])[n:6][cH:7]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 81531DiisopropylethylamineHCID 2899735-Bromo-2,4-dichloropyrimidineHCID 2756045tert-butyl N-[4-(aminomethyl)cyclohexyl]carbamate

Product 1

HCID 57885536{4-[(5-Bromo-2-chloro-pyrimidin-4-ylamino)-methyl]-cyclohexyl}-carbamic acid tert-butyl ester

Sources & evidence

ORD record
ord-297bf8aee5de4b4a906418979f75e62a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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