Tetrahydrofuran → HCID 86653948, compound

HRID 2088408Notes

Reaction equation

HRID 2088408 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([C:9]2[N:14]=[CH:13][C:12](/[CH:15]=[CH:16]/[CH2:17][NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])(C)C)=[CH:11][N:10]=2)[CH:6]=[CH:7][CH:8]=1.[CH2:26]1COC[CH2:27]1>[Pt]>[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([C:9]2[N:10]=[CH:11][C:12]([CH2:15][CH2:16][CH2:17][NH:18][C:19](=[O:25])[O:20][CH2:21][CH2:24][CH2:26][CH3:27])=[CH:13][N:14]=2)[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 58289707HCID 58289707, compound

Product 1

HCID 86653948HCID 86653948, compound

Reagents, catalysts & solvents 1

HCID 23939PlatinumCatalyst

Procedure

280 mg (0.82 mmol) of tert-butyl {(E)-3-[2-(3-hydroxymethylphenyl)pyrimidin-5-yl]allyl}carbamate are dissolved in 10 ml of THF, shaken at room temperature for 17 h with 300 mg of platinum on active carbon (5%, comprises 56% of water) under a hydrogen atmosphere. The catalyst is filtered off with suction, and the filtrate is evaporated to dryness.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. customthe filtrate is evaporated to dryness

Sources & evidence

ORD record
ord-6c7a93d1229e40ebab3558dfb5a5cfa1
Source dataset
uspto-grants-2013_05
Patent number
US08435986B2

Reaction notes

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