Iodine → HCID 178526522, compound

HRID 2089571Notes

Reaction equation

HRID 2089571 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][N:10]=[CH:9]2)([O-:3])=[O:2].[OH-].[K+].[I:15]I>CN(C=O)C.S(=O)(=O)(O)[O-].[Na+]>[I:15][C:9]1[C:8]2[C:12](=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=[CH:6][CH:7]=2)[NH:11][N:10]=1

Participants

6

Reactant 3

HCID 807IodineHCID 18937-NitroindazoleHCID 14797Potassium Hydroxide

Product 1

HCID 178526522HCID 178526522, compoundYield 88.3%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 516919Sodium BisulfateSolvent

Procedure

7-Nitroindazole (1.60 g, 9.80 mmol) was dissolved in DMF (100 mL), and potassium hydroxide (2.20 g, 39.20 mmol) and iodine (4.98 g, 19.61 mmol) were added in drops thereto. After stirring for 2 h, the reaction mixture was diluted with 10% aqueous sodium bisulfate solution. The resulting solid was collected and dried to give the title compound (2.50 g, Yield 88%).

Workup

  1. customThe resulting solid was collected
  2. customdried

Sources & evidence

ORD record
ord-e50c98c9833d45689096f1afbdafc469
Source dataset
uspto-grants-2013_05
Patent number
US08436038B2

Reaction notes

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