1-Methyl-4-piperidone → HCID 68432258, compound

HRID 2090247Notes

Reaction equation

C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].[NH2:15][CH2:16][CH2:17][CH2:18][N:19]1[C:31]2[C:30]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[N:24]=[C:23]([NH2:32])[C:22]=2[N:21]=[C:20]1[CH2:33][CH2:34][CH2:35][CH3:36].[CH3:37][N:38]1[CH2:43][CH2:42][C:41](=O)[CH2:40][CH2:39]1>CN1C(=O)CCC1>[CH2:33]([C:20]1[N:19]([CH2:18][CH2:17][CH2:16][NH:15][CH:41]2[CH2:42][CH2:43][N:38]([CH3:37])[CH2:39][CH2:40]2)[C:31]2[C:30]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[N:24]=[C:23]([NH2:32])[C:22]=2[N:21]=1)[CH2:34][CH2:35][CH3:36]

Participants

Conditions

Temperature: 50 °C

Procedure

Sodium triacetoxyborohydride (1.07 g) was added to a stirred mixture of the product from example 1 step (vii) (502 mg) and 1-methylpiperidin-4-one (0.21 mL) in NMP (2 mL) at rt. The resulting solution was stirred at 50° C. for 3 h, then purified by SCX, yield 335 mg.

Workup

custompurified by SCX, yield 335 mg

Sources & evidence

ORD record: ord-d823c63b6a4c443a877a403f80b6d0f4
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08436178B2

Reaction notes

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