Hydrochloric Acid → Hydrochloric Acid

HRID 2090329Notes

Reaction equation

HRID 2090329 reaction equation
[CH3:1][N:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][CH2:10][N:11](C(OC(C)(C)C)=O)[CH2:12][CH:13]=2)=[CH:4][C:3]1=[O:21].[ClH:22].O1CCOCC1>CCOC(C)=O>[ClH:22].[CH3:1][N:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH:13]=2)=[CH:4][C:3]1=[O:21].[ClH:22]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59402379HCID 59402379, compound

Product 2

HCID 313Hydrochloric AcidHCID 67436681HCID 67436681, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of tert-Butyl 1′-methyl-2′-oxo-1′,2′,3,6-tetrahydro-4,4′-bipyridine-1(2H)-carboxylate (100 mg, 0.3 mmol) in AcOEt (2 mL) was treated with 4 M of hydrogen chloride in 1,4-dioxane (0.1722 mL, 0.6888 mmol). The mixture was stirred at r.t. 2 h., and concentrated under reduced pressure to afford the desired compound as HCl salt which was directly used in the next step reaction without further purification. LCMS (M+H)+: m/z=191.1.

Workup

  1. concentration2 h., and concentrated under reduced pressure

Sources & evidence

ORD record
ord-39691f27a1974f3ca3d45e193fcfef4c
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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