Water → 1-Bromo-3-((4-(difluoromethoxy)phenyl)ethynyl)benzene

HRID 209035Notes

Reaction equation

HRID 209035 reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:8]#[CH:9])[cH:5][cH:6][cH:7]1.[CH3:21][CH2:22][O:23][C:24]([CH3:25])=[O:26].[Cu:33][I:34].[I:10][c:11]1[cH:12][cH:13][c:14]([O:17][CH:18]([F:19])[F:20])[cH:15][cH:16]1.[O:28]=[CH:29][N:30]([CH3:31])[CH3:32].[OH2:27]>>[Br:1][c:2]1[cH:3][c:4]([C:8]#[C:9][c:11]2[cH:12][cH:13][c:14]([O:17][CH:18]([F:19])[F:20])[cH:15][cH:16]2)[cH:5][cH:6][cH:7]1

Participants

7

Reactant 6

HCID 962WaterHCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 27370081-(Difluoromethoxy)-4-iodobenzeneHCID 114808181-Bromo-3-ethynylbenzene

Product 1

HCID 597903321-Bromo-3-((4-(difluoromethoxy)phenyl)ethynyl)benzene

Sources & evidence

ORD record
ord-afd6011d12254d1cbebdd73acd95e10e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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