4-Methylmorpholine → n-(2-Aminophenyl)-5-(biphenyl-4-ylcarbonyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide

HRID 2093057Notes

Reaction equation

[C:1]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][C:4]([C:7]([OH:9])=O)=[CH:3][CH:2]=1.ON1C2C=CC=CC=2N=N1.C(N=C=NCCCN(C)C)C.CN1CCOCC1.[NH2:44][C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][C:46]=1[NH:51][C:52]([C:54]1[S:55][C:56]2[CH2:57][NH:58][CH2:59][CH2:60][C:61]=2[N:62]=1)=[O:53]>CN(C=O)C>[NH2:44][C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][C:46]=1[NH:51][C:52]([C:54]1[S:55][C:56]2[CH2:57][N:58]([C:7]([C:4]3[CH:3]=[CH:2][C:1]([C:10]4[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=4)=[CH:6][CH:5]=3)=[O:9])[CH2:59][CH2:60][C:61]=2[N:62]=1)=[O:53]

Participants

Conditions

Temperature: 0 °C

Procedure

To a solution of biphenyl-4-carboxylic acid (1.0 mmol) in dry 10 mL DMF, were added 1-hydroxybenzotriazole (1.2 mmol), 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide (2 mmol) and N-methylmorpholine (2.0 mmol). Solution was cooled to 0° C.N-(2-aminophenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide obtained from step VIII of example 1 (1.1 mmole.) was then added and mixture was stirred at room temperature overnight. Reaction mixture was concentrated, diluted with water, extracted with dichloromethane, washed with brine solution, and dried over anhydrous Na2SO4. Concentrated and purified by column chromatography to yield the title compound.

Workup

customReaction mixture
concentrationwas concentrated
additiondiluted with water
extractionextracted with dichloromethane
washwashed with brine solution
dry with materialdried over anhydrous Na2SO4
concentrationConcentrated
custompurified by column chromatography

Sources & evidence

ORD record: ord-50bf951b9f1b439b8af8161298520a62
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08440830B2

Reaction notes

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