反应详情

温度

0 °C

Triethyl amine (1.0 eq) was added to solution of N-(2-aminophenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide obtained in step VIII of example I (1.0 mmol) in 10 mL THF. The solution was cooled to 0° C. 4-Methyl-benzenesulfonyl chloride (1.0 mmol) was added slowly with continuous stirring. Reaction mixture was brought to room temperature and stirred for 2 h Reaction mixture was concentrated, diluted with water, extracted dichloromethane, washed with brine solution, and dried over anhydrous Na2SO4. Concentrated and purified by column chromatography to yield the title compound.

1. customReaction mixture
2. customwas brought to room temperature
3. customReaction mixture
4. concentrationwas concentrated
5. additiondiluted with water
6. extractionextracted dichloromethane
7. washwashed with brine solution
8. dry with materialdried over anhydrous Na2SO4
9. concentrationConcentrated
10. custompurified by column chromatography