反应详情

To a solution of 5-[(4-methylphenyl)sulfonyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid (1.0 eq) obtained from step IV in DMF was added Et3N (2.2 eq.), EDCI (1.2 eq) and HOBt ((1.2 eq) and reaction was stirred for 1 h Phenylene diamine was added and reaction was stirred for overnight. Reaction was then quenched with water and extracted with ethyl acetate. Organic layer was separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford crude product, which, on purification by column chromatography afforded the title compound.

1. custom(1.2 eq) and reaction
2. additionwas added
3. customreaction
4. customReaction
5. customwas then quenched with water
6. extractionextracted with ethyl acetate
7. customOrganic layer was separated
8. dry with materialdried over anhydrous Na2SO4
9. concentrationconcentrated under reduced pressure
10. customto afford crude product, which
11. customon purification by column chromatography