Hydrochloric Acid → HCID 5702423, compound

HRID 2093099Notes

Reaction equation

HRID 2093099 reaction equation
[N+:1]([CH3:4])([O-:3])=[O:2].[OH-].[Na+].[S:7]1[CH:11]=[CH:10][C:9]([CH:12]=O)=[CH:8]1.Cl>C(O)C>[N+:1](/[CH:4]=[CH:12]/[C:9]1[CH:10]=[CH:11][S:7][CH:8]=1)([O-:3])=[O:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6375NitromethaneHCID 14798Sodium HydroxideHCID 681353-Thiophenecarboxaldehyde

Product 1

HCID 5702423HCID 5702423, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of nitromethane (1.15 eq.) in ethanol (30 ml per gm of aldehyde) cooled to 0° C. was added dropwise a solution of 10N NaOH and stirred for 15 min. 3-thiopene carbaldehyde was added slowly under slitting at 0° C. and resulting reaction mixture was stirred for 1 hr. Reaction mixture was then poured on 10% icecold HCl solution and yellow solid was filtered and dried to yield the desired 3-[(E)-2-nitrovinyl]thiophene.

Workup

  1. customunder slitting at 0° C.
  2. customresulting
  3. customreaction mixture
  4. stirringwas stirred for 1 hr
  5. customReaction mixture
  6. filtrationwas filtered
  7. customdried

Sources & evidence

ORD record
ord-d290f77b732446a694900dde620da3c9
Source dataset
uspto-grants-2013_05
Patent number
US08440830B2

Reaction notes

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