Water → HCID 68726219, compound

HRID 2093650Notes

Reaction equation

HRID 2093650 reaction equation
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=O)=[CH:4][C:3]=1[O:11][C:12]([F:15])([F:14])[F:13].N1C(Cl)=NC(Cl)=NC=1Cl.O>CN(C)C=O>[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]#[N:8])=[CH:4][C:3]=1[O:11][C:12]([F:13])([F:14])[F:15]

Participants

5

Reactant 3

HCID 962WaterHCID 7954Cyanuric chlorideHCID 68724707HCID 68724707, compound

Product 1

HCID 68726219HCID 68726219, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 4-hydroxy-3-(trifluoromethoxy)benzamide (532 mg, 2.41 mmol) in dimethylformamide (3 ml) was added cyanuric chloride (223 mg, 1.21 mmol). The mixture was stirred for 25 and then water was added and the resulting solution was extracted 3 times with ethyl acetate. The combined organics were washed with brine, dried over sodium sulfate, and concentrated in vacuo to afford the title compound. Mass spectrum (ESI) 202.1 (M−1).

Workup

  1. extractionthe resulting solution was extracted 3 times with ethyl acetate
  2. washThe combined organics were washed with brine
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-aec3fb1e187749468b29b12beaa4a742
Source dataset
uspto-grants-2013_05
Patent number
US08445480B2

Reaction notes

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