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HRID2095276

反应详情

EQUATION

反应方程式

HRID 2095276 的结构方程式

REACTANTS

反应物

4
结构：Cc1cc(O)cc(O)c1
HCID10436

1,3-Dihydroxy-5-methylbenzene

C7H8O2

结构：c1ccc(P(c2ccccc2)c2ccccc2)cc1
HCID11776

Triphenylphosphine

C18H15P

结构：O=C(/N=N/C(=O)OCc1ccccc1)OCc1ccccc1
HCID5387121

未命名化合物

结构：CCOC(=O)c1[nH]c2c(Br)cccc2c1CCCOc1cccc2ccccc12
HCID68938945

Ethyl 7-bromo-3-[3-(1-naphthalenyloxy)propyl]-1H-indole-2-carboxylate

C24H22BrNO3

PRODUCTS

生成物

1
结构：CCOC(=O)c1[nH]c2c(Br)cccc2c1CCCOc1cc(C)cc(O)c1
HCID68939274

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

A suspension of ethyl 7-bromo-3-(3-hydroxypropyl)-1H-indole-2-carboxylate (EXAMPLE 1C) (0.9 g), 5-methylbenzene-1,3-diol (1.028 g), triphenylphosphine (0.868 g), dibenzylazodicarboxylate (0.762 g) and tetrahydrofuran (40 ml) was stirred at room temperature for 19 hours. After removal of the solvent, the crude product was purified by flash chromatography silica gel, (Analogix, SF65-200 g) eluting with 0-10% ethyl acetate in hexane.

WORKUP

后处理

  1. customAfter removal of the solvent
  2. customthe crude product was purified by flash chromatography silica gel
  3. wash(Analogix, SF65-200 g) eluting with 0-10% ethyl acetate in hexane