Diethyl (ethoxymethylene)malonate → HCID 58158628, compound

HRID 2095813Notes

Reaction equation

HRID 2095813 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][NH2:9].Cl.C(=O)([O-])[O-].[K+].[K+].C([O:19][CH:20]=[C:21]([C:27](OCC)=O)[C:22]([O:24][CH2:25][CH3:26])=[O:23])C>O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:20](=[O:19])[C:21]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:27][NH:9]1

Participants

5

Reactant 3

HCID 6871Diethyl (ethoxymethylene)malonateHCID 11430Potassium CarbonateHCID 4432872-Chlorophenylhydrazine hydrochloride

Product 1

HCID 58158628HCID 58158628, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In the same manner as in Reference Example 63 and using (2-chlorophenyl)hydrazine•hydrochloride (5 g, 28 mmol), water (100 mL), potassium carbonate (8.5 g, 62 mmol) and diethyl ethoxymethylenemalonate (7.3 g, 34 mmol) as starting materials, the title compound (5.8 g, 78%) was obtained as a white solid.

Sources & evidence

ORD record
ord-73c5d82c64d0478d9cbfd71b4939f4ba
Source dataset
uspto-grants-2013_05
Patent number
US08445509B2

Reaction notes

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