Diethyl (ethoxymethylene)malonate → HCID 58158459, compound

HRID 2095816Notes

Reaction equation

HRID 2095816 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][NH2:10].Cl.C(=O)([O-])[O-].[K+].[K+].C([O:20][CH:21]=[C:22]([C:28](OCC)=O)[C:23]([O:25][CH2:26][CH3:27])=[O:24])C>O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:21](=[O:20])[C:22]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:28][NH:10]1

Participants

5

Reactant 3

HCID 6871Diethyl (ethoxymethylene)malonateHCID 11430Potassium CarbonateHCID 27333012,4-Difluorophenylhydrazine hydrochloride

Product 1

HCID 58158459HCID 58158459, compoundYield 66.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In the same manner as in Reference Example 63 and using (2,4-difluorophenyl)hydrazine•hydrochloride (5.1 g, 28 mmol), water (100 mL), potassium carbonate (8.6 g, 62 mmol) and diethyl ethoxymethylenemalonate (7.4 g, 34 mmol) as starting materials, the title compound (5.0 g, 66%) was obtained as a pale-yellow solid.

Sources & evidence

ORD record
ord-3263d2b169034d7395a46cfbdb7acc57
Source dataset
uspto-grants-2013_05
Patent number
US08445509B2

Reaction notes

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