Diethyl (ethoxymethylene)malonate → HCID 58158589, compound

HRID 2095819Notes

Reaction equation

HRID 2095819 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][NH2:10].Cl.C(=O)([O-])[O-].[K+].[K+].C([O:20][CH:21]=[C:22]([C:28](OCC)=O)[C:23]([O:25][CH2:26][CH3:27])=[O:24])C>O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:21](=[O:20])[C:22]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:28][NH:10]1

Participants

5

Reactant 3

HCID 6871Diethyl (ethoxymethylene)malonateHCID 11430Potassium CarbonateHCID 28494452-Methoxyphenylhydrazine Hydrochloride

Product 1

HCID 58158589HCID 58158589, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In the same manner as in Reference Example 63 and using (2-methoxyphenyl)hydrazine•hydrochloride (5.3 g, 30 mmol), water (100 mL), potassium carbonate (9.1 g, 66 mmol) and diethyl ethoxymethylenemalonate (7.8 g, 36 mmol) as starting materials, the title compound (6.1 g, 78%) was obtained as a white solid.

Sources & evidence

ORD record
ord-7328a6bb9ff0435daecc51b68e24f9a2
Source dataset
uspto-grants-2013_05
Patent number
US08445509B2

Reaction notes

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