Diethyl (ethoxymethylene)malonate → HCID 66968556, compound

HRID 2095822Notes

Reaction equation

HRID 2095822 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][NH2:10].Cl.C(=O)([O-])[O-].[K+].[K+].C([O:20][CH:21]=[C:22]([C:28](OCC)=O)[C:23]([O:25][CH2:26][CH3:27])=[O:24])C>O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]1[C:21](=[O:20])[C:22]([C:23]([O:25][CH2:26][CH3:27])=[O:24])=[CH:28][NH:10]1

Participants

5

Reactant 3

HCID 6871Diethyl (ethoxymethylene)malonateHCID 11430Potassium CarbonateHCID 2723909(2,6-Dichlorophenyl)hydrazine monohydrochloride

Product 1

HCID 66968556HCID 66968556, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In the same manner as in Reference Example 63 and using (2,6-dichlorophenyl)hydrazine•hydrochloride (4.8 g, 23 mmol), water (100 mL), potassium carbonate (6.9 g, 50 mmol) and diethyl ethoxymethylenemalonate (5.9 g, 27 mmol) as starting materials, the title compound (5.0 g, 73%) was obtained as a pale-yellow solid.

Sources & evidence

ORD record
ord-b662c7dad6c543a7a123643c8cb0bd37
Source dataset
uspto-grants-2013_05
Patent number
US08445509B2

Reaction notes

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