反应详情

To a solution of benzylcarbamate {4-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]phenyl}carbamate (8.7 g, 22.2 mmol) in N,N-dimethylacetamide (70 mL) was added cyclopropanecarbonyl chloride (2.21 mL, 24.4 mmol) at room temperature, and the mixture was stirred at room temperature for 1 hr. Saturated aqueous sodium hydrogen carbonate was added to the reaction mixture, and the mixture was extracted with ethyl acetate/tetrahydrofuran. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and filtered. The solvent was evaporated under reduced pressure, and the residue was washed with hexane/ethyl acetate (=1/1) and collected by filtration to give the title compound (8.5 g, 87%) as a thin-brown solid.

1. extractionthe mixture was extracted with ethyl acetate/tetrahydrofuran
2. washThe organic layer was washed with saturated brine
3. dry with materialdried over anhydrous magnesium sulfate
4. filtrationfiltered
5. customThe solvent was evaporated under reduced pressure
6. washthe residue was washed with hexane/ethyl acetate (=1/1)
7. filtrationcollected by filtration