反应详情

温度

95 °C

6-Bromohexanenitrile (2.65 mL, 20 mmol) and 4-chlorophenol (2.57 g, 20 mmol) were dissolved in DMF (50 mL). After addition of K2CO3 (5.53 g, 40 mmol) the mixture was stirred at 95° C. for 3 h. The solvent was evaporated under reduced pressure and the residue was partitioned between water (80 mL) and Et2O (200 mL). The org. layer was separated, washed with pH 7 phosphate buffer solution (1×50 ml), dried over Na2SO4, filtered and the solvent was removed under reduced pressure to give the title compound, pure enough for further reactions.

1. customThe solvent was evaporated under reduced pressure
2. customthe residue was partitioned between water (80 mL) and Et2O (200 mL)
3. customlayer was separated
4. washwashed with pH 7 phosphate buffer solution (1×50 ml)
5. dry with materialdried over Na2SO4
6. filtrationfiltered
7. customthe solvent was removed under reduced pressure