反应详情

To a solution of 5-(2-methoxy-vinyl)-7-methyl-1H-indazole (365 mg, 1.94 mmol, 1.0 equiv.) in tetrahydrofuran (8 mL) was added 60% perchloric acid (0.63 mL, 3 equiv) in one portion under nitrogen. After 2 h, more perchloric acid (0.63 mL) was added. After 4 h, LCMS indicated that no starting material was present. The reaction mixture was diluted with water and ethyl acetate. The layers were separated and the organic layer was washed with water (3×). The organic layer was separated, dried over sodium sulfate and concentrated in vacuo to give an off-white solid. The crude material was carried on without further purification. MS (ESI) [M+H]+=175.

1. waitAfter 4 h
2. customThe layers were separated
3. washthe organic layer was washed with water (3×)
4. customThe organic layer was separated
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated in vacuo
7. customto give an off-white solid
8. customThe crude material was carried on without further purification