反应详情

Potassium carbonate (1.22 g, 8.82 mmol), DMSO (0.44 ml), and hydrogen peroxide (0.9 ml of a 30% solution in H2O) were added to a suspension of N-(3-cyano-pyridin-2-yl)-2-phenethyloxy-acetamide (400 mg, 1.42 mmol) in methanol (6 ml). After 3 h at r.t., the mixture was taken up in ethyl acetate, and washed with salt. NH4Cl. The solution was dried (Na2SO4) and the solvent was evaporated. The residue was triturated with tert-butyl methyl ether to give the title compound. MS: m/e=280.4 [M−H−], 1H NMR (d6-DMSO): 2.91 (t, 2H), 3.78 (t, 2H), 4.45 (s, 2H), 7.17-7.22 (m, 5H), 7.53 (dd, 1H), 8.49 (d, 1H), 8.93 (d, 1H), 12.44 (bs, 1H).

1. washwashed with salt
2. dry with materialThe solution was dried (Na2SO4)
3. customthe solvent was evaporated
4. customThe residue was triturated with tert-butyl methyl ether