Lithium Hydroxide → 5-Butyl-2-chloro-nicotinic acid

HRID 2100552Notes

Reaction equation

HRID 2100552 reaction equation
C[O:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8]([CH2:10][CH2:11][CH2:12][CH3:13])[CH:7]=[N:6][C:5]=1[Cl:14].[Li+].[OH-]>C1COCC1>[CH2:10]([C:8]1[CH:7]=[N:6][C:5]([Cl:14])=[C:4]([CH:9]=1)[C:3]([OH:15])=[O:2])[CH2:11][CH2:12][CH3:13]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 866166085-Butyl-2-chloro-nicotinic acid methyl ester

Product 1

HCID 866166095-Butyl-2-chloro-nicotinic acid

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In analogy to the procedure described in example 124.1, 5-butyl-2-chloro-nicotinic acid methyl ester was treated with LiOH in THF to give 5-butyl-2-chloro-nicotinic acid as colorless crystals. MS: m/e=212.2 [M−H−].

Sources & evidence

ORD record
ord-32bfb09433f54df3b3691c38bbe81b4c
Source dataset
uspto-grants-2009_08
Patent number
US07572801B2

Reaction notes

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