Hydrochloric Acid → HCID 16781337, compound

A solution of ethanesulfonyl chloride (3.9 ml, 41.1 mmol) in dioxane (10 ml) was added to a solution of 6-aminohexanoic acid (2 g, 15.2 mmol) in 1N NaOH (56 ml) and dioxane (10 ml), while stirring at 0° C.-5° C. The pH of the reaction mixture was adjusted to 8-9 by addition of 25% sodium hydroxide solution. The mixture was allowed to warm to room temperature and stirred for 30 minutes. Further 25% NaOH solution was added to adjust the pH to about 11. After 3.5 h 1N hydrochloric acid (15 ml) and ethyl acetate (60 ml) were added. The organic layer was dried over sodium sulfate and concentrated. The residue was triturated with a mixture of diethyl ether (5 ml) and hexane (15 ml). The solid was collected by filtration and dried affording 1.3 g of the title compound (40% yield).

1. stirringstirred for 30 minutes
2. dry with materialThe organic layer was dried over sodium sulfate
3. concentrationconcentrated
4. customThe residue was triturated with a mixture of diethyl ether (5 ml) and hexane (15 ml)
5. filtrationThe solid was collected by filtration
6. customdried

ORD record

ord-193d874a2858432682aa1b45e3d2dd4d

Source dataset

uspto-grants-2009_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07576206B2