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温度

0 °C

To 2-phenylimidazole (500 mg, 3.47 mmol) in 10 mL THF at 0° C., was added 60% NaH (146 mg, 3.64 mmol). The mixture was stirred at 0° C. for 15 min, then BOM-Cl (80%, 656 μL, 3.82 mmol) was added. The mixture was stirred at rt for 1 h, then was diluted with EtOAc. The organic phase was washed with H2O and brine, dried (Na2SO4) and concentrated. The crude product was purified by flash chromatography (0 to 100% EtOAc/hexanes gradient) to afford 630 mg of Intermediate 15.1 as a colorless oil.

1. stirringThe mixture was stirred at rt for 1 h
2. washThe organic phase was washed with H2O and brine
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated
5. customThe crude product was purified by flash chromatography (0 to 100% EtOAc/hexanes gradient)